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Lee S Rosen Selected Research

TER 286 (TLK286)

6/2004Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies.
5/2003Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

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Lee S Rosen Research Topics

Disease

51Neoplasms (Cancer)
01/2022 - 03/2002
11Colorectal Neoplasms (Colorectal Cancer)
10/2017 - 04/2002
10Diarrhea
01/2017 - 04/2002
9Fatigue
01/2018 - 07/2010
8Nausea
01/2017 - 08/2003
8Neoplasm Metastasis (Metastasis)
01/2017 - 12/2002
8Vomiting
01/2017 - 08/2003
7Breast Neoplasms (Breast Cancer)
01/2020 - 12/2002
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 12/2012
5Neutropenia
03/2016 - 06/2009
5Disease Progression
12/2014 - 07/2011
5Spinal Cord Compression
11/2004 - 08/2003
5Spontaneous Fractures (Pathological Fracture)
11/2004 - 08/2003
4Thrombocytopenia (Thrombopenia)
03/2016 - 12/2011
4Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2015 - 07/2010
4Hypertension (High Blood Pressure)
12/2014 - 10/2008
3Renal Cell Carcinoma (Grawitz Tumor)
12/2014 - 07/2010
3Sarcoma (Soft Tissue Sarcoma)
12/2014 - 11/2013
3Carcinoma (Carcinomatosis)
06/2013 - 04/2002
3Anemia
09/2012 - 08/2003
3Pain (Aches)
03/2010 - 08/2003
3Lung Neoplasms (Lung Cancer)
11/2004 - 12/2002
3Prostatic Neoplasms (Prostate Cancer)
05/2004 - 12/2002
2Colonic Neoplasms (Colon Cancer)
10/2021 - 12/2005
2Stomatitis
01/2018 - 11/2006
2Exanthema (Rash)
01/2018 - 10/2016
2Melanoma (Melanoma, Malignant)
10/2016 - 01/2016
2Leukopenia
03/2016 - 12/2011
2Glioblastoma (Glioblastoma Multiforme)
01/2016 - 12/2014
2Constipation
03/2015 - 11/2014
2Hepatocellular Carcinoma (Hepatoma)
12/2014 - 02/2014
2Hypoxia (Hypoxemia)
02/2014 - 03/2002
2Mucositis
11/2006 - 04/2003
2Multiple Myeloma
10/2003 - 12/2002
1Tremor (Tremors)
01/2018
1Anorexia
01/2017
1Hypocalcemia
01/2017
1Edema (Dropsy)
10/2016
1Hematologic Neoplasms (Hematological Malignancy)
11/2015
1Febrile Neutropenia
11/2015

Drug/Important Bio-Agent (IBA)

7Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2014 - 03/2002
7Zoledronic Acid (Zometa)FDA Link
11/2004 - 12/2002
6Pharmaceutical PreparationsIBA
03/2016 - 03/2010
5Fluorouracil (Carac)FDA LinkGeneric
10/2021 - 04/2003
5Monoclonal AntibodiesIBA
01/2021 - 03/2010
5Bevacizumab (Avastin)FDA Link
01/2018 - 02/2014
4Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2017 - 06/2012
4Sunitinib (Sutent)FDA Link
01/2015 - 04/2007
4motesanib diphosphateIBA
11/2014 - 06/2007
3Proteins (Proteins, Gene)FDA Link
01/2018 - 11/2013
3Irinotecan (Camptosar)FDA LinkGeneric
11/2015 - 04/2002
3GemcitabineFDA Link
03/2015 - 11/2011
3EndoglinIBA
12/2014 - 09/2012
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
12/2014 - 10/2008
3carotuximabIBA
12/2014 - 09/2012
3ARQ 197IBA
12/2014 - 12/2011
3thiamine triphosphorate (TTP)IBA
07/2011 - 03/2010
3Fibroblast Growth Factor 7FDA Link
03/2008 - 04/2003
3Diphosphonates (Bisphosphonates)IBA
05/2004 - 12/2002
3Pamidronate (Aredia)FDA LinkGeneric
05/2004 - 10/2003
2cemiplimabIBA
01/2021 - 01/2020
2Aurora Kinase AIBA
03/2016 - 07/2015
2MLN 8237IBA
03/2016 - 07/2015
2trifluridine tipiracil drug combinationIBA
02/2016 - 11/2015
2navitoclaxIBA
11/2015 - 11/2015
2Imatinib Mesylate (Gleevec)FDA Link
01/2015 - 07/2011
2trebananibIBA
11/2014 - 07/2009
2Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2013 - 09/2013
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2007 - 04/2003
2TER 286 (TLK286)IBA
06/2004 - 05/2003
2Biological ProductsIBA
04/2003 - 07/2002
1creatine transporterIBA
10/2021
1Adenosine Triphosphate (ATP)IBA
10/2021
1CreatineIBA
10/2021
1Leflunomide (Arava)FDA LinkGeneric
10/2021
1Dihydroorotate DehydrogenaseIBA
10/2021
1Phosphocreatine (Neoton)IBA
10/2021
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2020
1Immunoconjugates (Immunoconjugate)IBA
01/2020
1PF-06650808IBA
01/2020
1p38 Mitogen-Activated Protein KinasesIBA
01/2018
1Creatine Kinase (Creatine Phosphokinase)IBA
01/2018
1Hyaluronic Acid (Hyaluronan)IBA
01/2018
1PEGPH20IBA
01/2018
1Biosimilar PharmaceuticalsIBA
10/2017
1Ferrosoferric Oxide (Magnetite)FDA Link
01/2017
1Contrast MediaIBA
01/2017
1emibetuzumabIBA
01/2017
1cobimetinibIBA
10/2016
1Hormones (Hormone)IBA
01/2016
1abemaciclibIBA
01/2016
1Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2016
1Cytotoxins (Cytolysins)IBA
11/2015
1SolutionsIBA
07/2015
1PowdersIBA
07/2015
1Dosage Forms (Dosage Form)IBA
07/2015

Therapy/Procedure

15Therapeutics
01/2018 - 12/2002
6Radiotherapy
01/2020 - 08/2003
6Drug Therapy (Chemotherapy)
11/2015 - 11/2006
1Palliative Care (Palliative Therapy)
01/2022